Intravenous infusions of heparin and penicillins

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Intravenous infusions of heparin and penicillins.

The chemical stability and anticoagulant activity of heparin (20 U/ml) were studied in five intravenous fluids at room temperature. Heparin remained stable and active for 24 hours in normal saline, but there was a rapid inactivation of 40 to 55% in solutions containing dextrose or lactate, as measured by chemical and biological methods.High concentrations of benzylpenicillin, ampicillin, or met...

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Heparin Resistance During and Post-Intravenous Nitroglycerin Infusion

      Nitroglycerin has been reported to reduce activated partial thromboplastin time (aPTT) values in patients treated with concurrent heparin and nitroglycerin. However, studies have yielded conflicting results. To determine whether intravenous nitroglycerin alters the anticoagulant effect of heparin, we prospectively evaluated twenty patients admitted for coronary angioplasty by measurin...

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Some of the factors governing the development of edema in the lungs are understood in broad terms. These factors are considered to be no different from those operative in the systemic vessels-increased hydrostatic pressure, decreased oncotic pressure, excessive permeability of the vessels, and decreased lymphatic drainage. Little specific quantitative information is available relative to the pu...

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Septicaemia from prolonged intravenous infusions.

Four cases of septicaemia in children were traced to contaminated intravenous infusions and volume control sets. In each case Pseudomonas cepacia was isolated from multiple blood cultures and from intravenous fluid within the volume control set. The first patient died of septicaemia after a long and complicated postoperative period. The other three patients received appropriate antibiotics afte...

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The effect of ethyl alcohol on the splanchnic or liver blood flow has been a matter of 'debate. According to earlier investigations [Starling (1)] ethanol has little effect on the cardiovascular system, its influence being mainly confined to a dilatation of the vessels of the skin and of the mucous membranes. The investigation of Smythe, Heinemann and Bradley on dogs (2) supported this concept....

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1973

ISSN: 0021-9746

DOI: 10.1136/jcp.26.10.742